CAPOX

Pre- and post-chemotherapy images of a T3 N1 M0 cStage IIIa colorectal cancer. Four courses of CAPOX therapy.

CAPOX (also called XELOX<ref>,

 XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients with Metastatic Colorectal Cancer, 
 Journal of Clinical Oncology, 
 2004,
 Vol. 22(Issue: 11),
 pp. 2084–2091,
 DOI: 10.1200/JCO.2004.11.069,
 PMID: 15169795,</ref>) is a chemotherapy regimen consisting of capecitabine (trade name Xeloda) combined with oxaliplatin.<ref>Capecitabine Combined with Oxaliplatin (CapOx) in Clinical Practice: How Significant is Peripheral Neuropathy? D. J. Storey; M. Sakala; C. M. McLean; H. A. Phillips; L. K. Dawson; L. R. Wall; M. T. Fallon; S. Clive. Posted: 09/28/2010; Annals of Oncology. 2010;21(8):1657-1661. © 2010 Oxford University Press</ref><ref>, 
 Capecitabine as adjuvant treatment for stage III colon cancer, 
 N. Engl. J. Med., 
 
 Vol. 352(Issue: 26),
 pp. 2696–704,
 DOI: 10.1056/NEJMoa043116,
 PMID: 15987918,</ref>

Xelox regime operates in 3-week cycles, usually with 8 cycles in total; Xeloda is orally taken for twice daily for two weeks, while oxaliplatin is administrated by IV on the first day of the cycle; there is a one-week rest period before the next cycle.

Adverse effects

• Neuropathy
• Diarrhea

References

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