Bolesatine
Bolesatine' is a glycoprotein isolated from the Rubroboletus satanas (previously known as Boletus satanas Lenz) mushroom, notable for its lectin properties with specificity to D-galactose sugar binding sites. This monomeric protein features a compact globular structure, characterized by its thermal stability, the presence of a single tryptophan in its primary sequence, and one disulfide bridge, contributing to its structural integrity and functional specificity.
Pronunciation
Bo-le-sa-tine
Structural and Functional Properties
Bolesatine's lectin function allows it to selectively bind to D-galactose, a monosaccharide found in various biomolecules. Its structure, defined by a single tryptophan and a disulfide bridge, underpins its stability and specificity. The compact globular form of this protein enhances its thermostability, making it resistant to denaturation at elevated temperatures.
Toxicological Effects
Exposure to bolesatine can lead to poisoning, manifesting as the accumulation of toxins in the liver and other organs. At threshold concentrations, bolesatine induces agglutination of human red blood cells and platelets, leading to symptoms such as hypertension and dizziness. In severe cases, bolesatine poisoning may result in death, underscoring the potential hazards associated with ingestion of Rubroboletus satanas mushrooms.
Symptoms of Bolesatine Poisoning
- Agglutination of red blood cells and platelets
- Hypertension
- Dizziness
- Potential organ damage
- In severe cases, death
Related Terms
See Also
External links
- Medical encyclopedia article on Bolesatine
- Wikipedia's article - Bolesatine
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