Basal-like carcinoma

Basal-like Carcinoma

Basal-like carcinoma (pronunciation: /ˈbeɪsəl laɪk kɑːrsɪˈnoʊmə/) is a subtype of breast cancer that is characterized by specific molecular features. The term "basal-like" is derived from the fact that these cancers have gene expression profiles that resemble those of the basal cells of the normal breast.

Etymology

The term "basal-like carcinoma" is derived from the word "basal", which refers to the base or bottom layer of the epithelial cells, and "carcinoma", which is a type of cancer that starts in cells that make up the skin or the tissue lining organs.

Definition

Basal-like carcinoma is a subtype of triple-negative breast cancer that lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and does not have an excess of the HER2 protein on the cancer cell surfaces. These cancers are more likely to affect younger women and women of African ancestry.

Related Terms

• Breast Cancer
• Triple-negative breast cancer
• Estrogen receptor
• Progesterone receptor
• HER2/neu

See Also

• Luminal A breast cancer
• Luminal B breast cancer
• HER2-enriched breast cancer

External links

• Medical encyclopedia article on Basal-like carcinoma
• Wikipedia's article - Basal-like carcinoma

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