BMPR1B
BMPR1B
BMPR1B (pronounced as B-M-P-R-One-B), also known as Bone Morphogenetic Protein Receptor Type-1B, is a protein that in humans is encoded by the BMPR1B gene.
Etymology
The term BMPR1B is an abbreviation derived from Bone Morphogenetic Protein Receptor, 1st type, B subtype. The term "morphogenetic" is derived from the Greek words "morphê" meaning shape and "genesis" meaning creation.
Function
BMPR1B is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their presence for signaling, whereas type I receptors require their presence for ligand binding.
Related Terms
- Bone Morphogenetic Protein (BMP): A group of growth factors also known as cytokines and as metabologens.
- Serine/Threonine Kinase Receptors: A group of cell surface receptors that respond to several ligands, including bone morphogenetic protein (BMP).
- Endochondral Ossification: The process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone.
- Embryogenesis: The process by which the embryo forms and develops.
See Also
External links
- Medical encyclopedia article on BMPR1B
- Wikipedia's article - BMPR1B
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