BAFF

BAFF (pronounced /bæf/), also known as B-cell activating factor, is a cytokine that belongs to the tumor necrosis factor (TNF) family. Its primary function is to promote B-cell maturation and survival.

Etymology

The term "BAFF" is an acronym derived from B-cell Activating Factor. It was first identified in 1999 and has since been the subject of extensive research due to its role in autoimmune diseases.

Function

BAFF is primarily produced by Monocytes and Dendritic cells. It plays a crucial role in the survival and maturation of B-cells, a type of white blood cell that produces antibodies. BAFF binds to three different receptors on B-cells: BAFF-R, TACI, and BCMA, each triggering different cellular responses.

Clinical Significance

High levels of BAFF have been associated with several Autoimmune diseases, including Systemic lupus erythematosus, Rheumatoid arthritis, and Sjögren's syndrome. This has led to the development of BAFF inhibitors as a therapeutic strategy for these conditions.

Related Terms

• B-cells
• Monocytes
• Dendritic cells
• Autoimmune diseases
• Systemic lupus erythematosus
• Rheumatoid arthritis
• Sjögren's syndrome

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