Artificial kidney

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Artificial Kidney

A hollow fiber hemodialyzer, a key component in artificial kidney technology.

An artificial kidney is a device that replicates the functions of a biological kidney, primarily used to perform dialysis for patients with kidney failure. The artificial kidney is a critical component in the treatment of end-stage renal disease (ESRD) and acute kidney injury (AKI).

Function

The primary function of an artificial kidney is to remove waste products and excess fluids from the blood, a process known as hemodialysis. This is achieved by passing the patient's blood through a dialyzer, which acts as a filter. The dialyzer contains a semi-permeable membrane that allows waste molecules and excess ions to pass through while retaining larger molecules like proteins and blood cells.

Components

The main components of an artificial kidney include:

  • Dialyzer: Often referred to as the "artificial kidney," the dialyzer is the core component where blood filtration occurs. It typically consists of a bundle of hollow fibers made from a semi-permeable membrane.
  • Dialysis machine: This machine pumps blood from the patient into the dialyzer and back, regulates the flow of dialysis fluid, and monitors various parameters such as blood pressure and fluid removal rate.
  • Dialysis fluid: Also known as dialysate, this fluid helps remove unwanted substances from the blood. It is carefully balanced to ensure the correct removal of waste products and electrolytes.

Types of Dialysis

There are two main types of dialysis that utilize artificial kidneys:

  • Hemodialysis: This is the most common form of dialysis, where blood is circulated outside the body through a dialyzer. It is typically performed in a dialysis center but can also be done at home.
  • Peritoneal dialysis: Although not using an artificial kidney in the traditional sense, this method uses the patient's peritoneum as a natural filter. A dialysis solution is introduced into the peritoneal cavity to absorb waste products.

Advances in Artificial Kidney Technology

Recent advances in artificial kidney technology focus on improving the efficiency and biocompatibility of dialyzers, reducing treatment times, and enhancing patient comfort. Research is ongoing into wearable and implantable artificial kidneys, which aim to provide continuous dialysis and improve the quality of life for patients with chronic kidney disease.

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Contributors: Prab R. Tumpati, MD