Arteriogenesis
Arteriogenesis
Arteriogenesis (/ɑːrˌtɪəri.oʊˈdʒɛnɪsɪs/) is a process in the body that leads to the formation and development of new arterial vessels. This process is a vital part of the body's response to conditions such as ischemia, where there is a lack of blood supply to a tissue, and in the healing of wounds.
Etymology
The term "arteriogenesis" is derived from the Greek words "arteria", meaning artery, and "genesis", meaning origin or creation.
Process
Arteriogenesis is initiated when an artery is blocked, leading to an increase in fluid shear stress in the pre-existing collateral arteries. This triggers the release of various growth factors and cytokines, which in turn stimulate the proliferation and migration of endothelial cells and smooth muscle cells. These cells then contribute to the enlargement of the collateral arteries, forming a new arterial vessel.
Related Terms
- Angiogenesis: The physiological process through which new blood vessels form from pre-existing vessels.
- Vasculogenesis: The process of blood vessel formation occurring by a de novo production of endothelial cells.
- Ischemia: A condition in which the blood flow (and thus oxygen) is restricted or reduced in a part of the body.
- Endothelial cell: A type of cell that lines the interior surface of blood vessels and lymphatic vessels.
- Smooth muscle cell: A type of non-striated muscle cell found in the walls of arteries and veins.
External links
- Medical encyclopedia article on Arteriogenesis
- Wikipedia's article - Arteriogenesis
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