Anti-dsDNA antibodies
Anti-dsDNA antibodies (pronunciation: an-tee-dee-es-dee-en-ay an-ti-bod-ees) are a type of autoantibody that specifically targets the deoxyribonucleic acid (DNA) in the cell nucleus. They are often found in people with certain autoimmune diseases, most notably Systemic Lupus Erythematosus (SLE).
Etymology
The term "Anti-dsDNA antibodies" is derived from the English language. "Anti-" is a prefix meaning against, "dsDNA" is an abbreviation for double-stranded DNA, and "antibodies" are proteins produced by the immune system to neutralize pathogens.
Function
Anti-dsDNA antibodies are produced by the immune system when it mistakenly identifies the body's own DNA as a foreign substance and launches an immune response against it. This can lead to inflammation and damage to various body tissues, a characteristic feature of autoimmune diseases.
Clinical Significance
Anti-dsDNA antibodies are a significant diagnostic marker for SLE, a chronic autoimmune disease that can affect any part of the body. They are present in approximately 70% of people with SLE and are rarely found in people without this disease. Testing for these antibodies is part of the diagnostic criteria for SLE.
Related Terms
- Autoimmune disease
- Systemic Lupus Erythematosus
- Autoantibody
- Deoxyribonucleic acid
- Immune system
- Inflammation
External links
- Medical encyclopedia article on Anti-dsDNA antibodies
- Wikipedia's article - Anti-dsDNA antibodies
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