Anrep effect
Anrep Effect
The Anrep Effect (pronunciation: /ˈænrɛp ɪˈfɛkt/) is a physiological phenomenon observed in the cardiac muscle.
Etymology
The Anrep Effect is named after the Russian physiologist Gleb von Anrep, who first described the phenomenon in 1912.
Definition
The Anrep Effect refers to the increase in contractility of the heart muscle that occurs in response to a slow increase in the afterload. This is a compensatory mechanism that allows the heart to maintain its output despite increased resistance.
Mechanism
The exact mechanism of the Anrep Effect is not fully understood. However, it is believed to involve the activation of the myocardial stretch receptors, which leads to an increase in the intracellular concentration of calcium ions. This, in turn, enhances the contractility of the cardiac muscle.
Related Terms
- Starling's law: Another physiological principle that describes how the heart adjusts its output in response to changes in venous return.
- Preload: The degree of stretch of the cardiac muscle fibers at the end of diastole.
- Afterload: The pressure that the heart must overcome to eject blood during systole.
- Contractility: The inherent ability of the cardiac muscle to contract independently of changes in preload or afterload.
See Also
External links
- Medical encyclopedia article on Anrep effect
- Wikipedia's article - Anrep effect
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