Androgen suppression

Androgen Suppression

Androgen suppression (pronounced: an-dro-jen suh-pre-shun) is a medical treatment method primarily used in the management of prostate cancer. The term originates from the words 'androgen', referring to any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics, and 'suppression', meaning to stop or reduce.

Overview

Androgen suppression therapy, also known as androgen deprivation therapy (ADT), involves reducing levels of androgens in the body to prevent them from reaching cancer cells. Androgens, such as testosterone, are hormones that are predominantly produced in the male testes, but are also produced in small amounts in the female ovaries and adrenal glands. They are responsible for typical male characteristics, such as facial hair and a deep voice.

Treatment

Androgen suppression can be achieved through surgery or medication. Surgical treatment involves the removal of the testes, in a procedure known as an orchiectomy. Medication options include luteinizing hormone-releasing hormone (LHRH) agonists and antagonists, antiandrogens, and other drugs that can reduce androgen production by the adrenal glands.

Side Effects

Potential side effects of androgen suppression therapy can include hot flashes, sexual dysfunction, loss of bone density (osteoporosis), anemia, and changes in body composition, such as increased body fat and decreased muscle mass.

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Androgen suppression