Alpha-2C adrenergic receptor
Alpha-2C adrenergic receptor (ADRA2C) is a G protein-coupled receptor that is encoded by the ADRA2C gene in humans. This receptor is part of the adrenergic receptor family, which plays a crucial role in the sympathetic nervous system.
Function
The Alpha-2C adrenergic receptor is a subtype of the alpha-2 adrenergic receptor, which mediates the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. This receptor is found in the brain and cardiovascular system, where it regulates the release of neurotransmitter and controls the dilation and constriction of blood vessels.
Clinical significance
Mutations in the ADRA2C gene have been associated with various disorders, including hypertension, congestive heart failure, and schizophrenia. In addition, drugs that target the Alpha-2C adrenergic receptor, such as clonidine and yohimbine, are used in the treatment of these conditions.
Pharmacology
The Alpha-2C adrenergic receptor is a target for several types of drugs, including alpha-2 adrenergic agonists and alpha-2 adrenergic antagonists. These drugs can either stimulate or inhibit the receptor, respectively, leading to various therapeutic effects.
See also
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