Alfred Gilman Sr.

American pharmacologist

Alfred Zack Gilman (February 5, 1908 – January 13, 1984) was a prominent American pharmacologist and physiologist known for his pioneering work in the field of chemotherapy. He co-authored the classic textbook The Pharmacological Basis of Therapeutics with Louis S. Goodman, which has been a fundamental resource for medical students and professionals in the field of pharmacology.

Early life and education

Alfred Gilman was born in Bridgeport, Connecticut. He attended Yale University, where he earned his undergraduate degree in 1928. He then pursued a medical degree at the Yale School of Medicine, graduating in 1931. During his time at Yale, Gilman developed a keen interest in pharmacology, which would shape his future career.

Career

After completing his medical degree, Gilman joined the faculty at the Yale School of Medicine as an instructor in pharmacology. In 1940, he moved to the University of Virginia, where he became a professor of pharmacology. It was during this time that he began collaborating with Louis S. Goodman on their seminal textbook.

The Pharmacological Basis of Therapeutics

Alfred Gilman Senior

In 1941, Gilman and Goodman published the first edition of The Pharmacological Basis of Therapeutics. This textbook was groundbreaking in its comprehensive coverage of pharmacology, integrating both basic science and clinical applications. It quickly became an essential resource for medical students and practitioners, and it has been updated regularly to reflect advances in the field.

Research and contributions

Gilman's research focused on the mechanisms of drug action and the development of new therapeutic agents. He was particularly interested in the use of chemotherapy for the treatment of cancer. His work laid the foundation for the development of modern cancer therapies and contributed significantly to the understanding of how drugs interact with biological systems.

Later life and legacy

Gilman continued to teach and conduct research until his retirement. He was a mentor to many students and young scientists, inspiring a new generation of pharmacologists. His contributions to the field were recognized with numerous awards and honors throughout his career.

Alfred Gilman passed away on January 13, 1984, leaving behind a legacy of scientific achievement and educational excellence. His textbook, The Pharmacological Basis of Therapeutics, remains a cornerstone of pharmacological education.

Related pages

• Pharmacology
• Chemotherapy
• Yale School of Medicine
• University of Virginia