Albert Kligman

American dermatologist and researcher

Albert Kligman

Albert Kligman

Albert Montgomery Kligman (March 17, 1916 – February 9, 2010) was an American dermatologist and researcher known for his work in the field of dermatology, particularly for the development of tretinoin (Retin-A) for the treatment of acne and photoaging.

Early Life and Education

Albert Kligman was born in Philadelphia, Pennsylvania. He attended University of Pennsylvania, where he earned his undergraduate degree. Kligman continued his education at the same institution, obtaining a Ph.D. in botany and later an M.D. from the University of Pennsylvania School of Medicine.

Career

Kligman began his career in dermatology at the University of Pennsylvania, where he conducted research on skin diseases and treatments. His work led to significant advancements in the understanding and treatment of various dermatological conditions.

Development of Tretinoin

Kligman is best known for his development of tretinoin, a derivative of vitamin A that became widely used in the treatment of acne and skin aging. Tretinoin was initially developed as a treatment for acne, but Kligman discovered its efficacy in reducing wrinkles and improving skin texture, leading to its use in anti-aging products.

Controversies

Kligman's career was not without controversy. He conducted research on inmates at Holmesburg Prison in Philadelphia, which later raised ethical concerns regarding informed consent and the treatment of human subjects in medical research. These studies were part of a broader pattern of medical experimentation on vulnerable populations during the mid-20th century.

Legacy

Despite the controversies, Kligman's contributions to dermatology have had a lasting impact. His work on tretinoin has helped millions of people manage acne and improve skin health. Kligman published numerous papers and was a respected figure in dermatological research.

Related pages

• Dermatology
• Tretinoin
• Acne
• Photoaging
• Holmesburg Prison experiments