Adozelesin
Adozelesin (pronunciation: /ædəˈzɛlɪsɪn/) is a synthetic alkylating agent used in cancer treatment. It is part of the CC-1065 group of drugs, which are designed to bind to the minor groove of DNA and disrupt its function.
Etymology
The term "Adozelesin" is derived from the abbreviation "ADO", which stands for Amino Dioxygenase, and "zelesin", which is a suffix commonly used in the naming of alkylating agents.
Pharmacology
Adozelesin works by binding to the minor groove of DNA, causing a bend in the DNA helix. This disrupts the normal function of the DNA, preventing the cancer cells from replicating and causing them to die. Adozelesin is a potent and selective alkylating agent, meaning it is able to target cancer cells more specifically than some other types of chemotherapy.
Related Terms
- Alkylating Agent: A type of drug that is used to treat cancer. It works by damaging the DNA of cancer cells, which prevents them from dividing and growing.
- CC-1065: A group of drugs that includes adozelesin. These drugs are designed to bind to the minor groove of DNA and disrupt its function.
- DNA: Deoxyribonucleic acid, the molecule that carries genetic information in all living organisms.
- Amino: A type of chemical group that contains a nitrogen atom and two hydrogen atoms.
- Dioxygenase: An enzyme that incorporates two oxygen atoms into its substrate.
See Also
External links
- Medical encyclopedia article on Adozelesin
- Wikipedia's article - Adozelesin
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