Methionine

Methionine is an essential amino acid that plays a crucial role in many biological processes. It is one of the 20 standard amino acids used by cells to synthesize proteins. Methionine is classified as an essential amino acid because it cannot be synthesized by the body and must be obtained from the diet.

Structure and Properties

Methionine is a large, non-polar, aliphatic amino acid. Its side chain contains a sulfur atom, making it one of the two sulfur-containing amino acids, the other being Cysteine. The sulfur atom in methionine is not reactive, unlike the one in cysteine, but it contributes to the hydrophobic nature of the amino acid.

Biological Role

Methionine plays several important roles in the body. It is involved in the initiation of protein synthesis, as it is always the first amino acid to be incorporated into a new protein. Methionine also plays a role in the synthesis of other important molecules in the body, such as S-adenosylmethionine (SAM), which is involved in the methylation of DNA and proteins.

Methionine is also a precursor to the amino acid cysteine, and it can donate the sulfur atom needed for the synthesis of cysteine. This is important because cysteine is a component of the antioxidant glutathione, which protects cells from damage by reactive oxygen species.

Dietary Sources and Requirements

Methionine is found in a variety of foods, with the highest amounts found in animal products such as meat, fish, and dairy products. Plant-based sources of methionine include nuts, seeds, and legumes, although these generally contain less methionine than animal-based sources.

The recommended dietary allowance (RDA) for methionine, combined with the other sulfur-containing amino acid cysteine, is 14 mg per kilogram of body weight for adults. This equates to approximately 1.05 g per day for a 75 kg adult.

Health Implications

A deficiency in methionine can lead to a variety of health problems, including liver damage, growth retardation, and skin lesions. Conversely, excessive intake of methionine, particularly in the form of supplements, can lead to elevated levels of homocysteine in the blood, which is a risk factor for cardiovascular disease.

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Methionine

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  Methionine

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  Methionine

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  S-Adenosyl-L-methionin

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  Methionine Biosynthesis

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  Methionine Pathway

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  Yang Cycle