ARSA

ARSA (pronounced: /ɑːrˈsɑː/), also known as Arylsulfatase A, is a crucial enzyme in the human body. It is primarily involved in the degradation of glycosphingolipids, specifically, sulfatides.

Etymology

The term "ARSA" is an acronym derived from Arylsulfatase A. Arylsulfatase refers to the type of enzyme it is, and the 'A' denotes its specific type within the arylsulfatase family.

Function

ARSA is responsible for the hydrolysis of sulfate esters from sulfatides, which are complex lipids found in the myelin sheath of nerve cells. This process is essential for the normal functioning of the nervous system.

Clinical Significance

Deficiency of ARSA leads to a rare genetic disorder known as Metachromatic Leukodystrophy (MLD). MLD is characterized by the accumulation of sulfatides in cells, particularly in the nerve cells, leading to progressive neurological symptoms.

Related Terms

• Enzyme
• Glycosphingolipids
• Sulfatides
• Metachromatic Leukodystrophy

See Also

• List of Enzymes
• Genetic Disorders

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