ADCC
ADCC
Antibody-dependent cellular cytotoxicity (ADCC) is a mechanism of immune response in which the immune system attacks and destroys target cells that are coated with antibodies. This process is an important aspect of the immune system's defense against pathogens and cancer cells.
ADCC is mediated by immune cells such as natural killer cells (NK cells), macrophages, and certain types of T cells. These cells express Fc receptors on their surface, which can bind to the Fc region of antibodies. When an antibody-coated target cell is recognized, the immune cell binds to the antibody and releases cytotoxic substances that kill the target cell.
The effectiveness of ADCC can be influenced by several factors, including the type and amount of antibodies present, the type of target cell, and the type of immune cell involved. In some cases, ADCC can also contribute to autoimmune diseases, when the immune system mistakenly attacks the body's own cells.
ADCC is a key mechanism of action for several therapeutic antibodies, including those used in the treatment of cancers and autoimmune diseases. By enhancing the ability of the immune system to recognize and destroy target cells, these therapies can help to control disease progression and improve patient outcomes.
External links
- Medical encyclopedia article on ADCC
- Wikipedia's article - ADCC
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