ABCC8
ABCC8 is a gene that provides instructions for making a protein that is part of a potassium channel. This channel, which spans the membrane of insulin-producing cells in the pancreas, regulates the flow of positively charged atoms (ions) into these cells. The channel is made up of four proteins produced from the ABCC8 gene and four proteins produced from another gene (KCNJ11). The activity of this channel is critical for maintaining normal insulin secretion and blood sugar levels.
Function[edit]
The ABCC8 gene provides instructions for making a protein that is part of a potassium channel. This channel, which spans the membrane of insulin-producing cells in the pancreas, regulates the flow of positively charged atoms (ions) into these cells. The channel is made up of four proteins produced from the ABCC8 gene and four proteins produced from another gene (KCNJ11). The activity of this channel is critical for maintaining normal insulin secretion and blood sugar levels.
Clinical significance[edit]
Mutations in the ABCC8 gene can cause several conditions related to insulin regulation. These conditions include hyperinsulinism, which is characterized by excessive insulin production, and several forms of diabetes, which involve impaired insulin secretion.
See also[edit]
References[edit]
External links[edit]
 | This medical article is a stub. You can help WikiMD by expanding the page. |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
