A23187

A23187

A23187 is a mobile ion-carrier that forms a stable complex with divalent cations (ions with a charge of +2). It is most commonly used in scientific research to increase intracellular calcium levels.

History

A23187, also known as Calcimycin, was first isolated in 1968 from Streptomyces chartreusensis. It was initially identified as an antibiotic, but its ability to transport divalent cations across biological membranes has made it a valuable tool in the study of cellular processes.

Structure and Function

A23187 is a diterpene compound with a complex ring structure. It forms a neutral complex with divalent cations, particularly calcium, and transports them across biological membranes. The transport process is not dependent on the membrane potential, making A23187 a powerful tool for manipulating intracellular calcium levels.

Applications

A23187 has been used in a wide range of biological research. It is often used to study the role of calcium in cellular processes, such as signal transduction, muscle contraction, and cell death. It has also been used to induce apoptosis, or programmed cell death, in cancer cells.

Safety

A23187 is toxic and should be handled with care. It can cause skin and eye irritation, and may be harmful if inhaled or swallowed.

See Also

• Ionophore
• Calcium signaling
• Apoptosis

References

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