60S ribosomal protein L37a

60S ribosomal protein L37a is a protein that in humans is encoded by the RPL37A gene. This protein is a component of the 60S ribosomal subunit which is part of the ribosome, the cell's molecular machine for protein synthesis. Ribosomal proteins play a key role in the function of the ribosome, facilitating the assembly of the ribosomal subunits and ensuring the proper translation of mRNA into protein.

Function

The 60S ribosomal protein L37a is involved in the structure and function of the ribosome. Along with other ribosomal proteins, it contributes to the formation of the peptidyl transferase center and the polypeptide exit tunnel, critical sites for protein synthesis. These proteins are essential for the accurate and efficient production of proteins within the cell, a process fundamental to all cellular operations and viability.

Gene

The RPL37A gene is located on chromosome 19 in humans. It encodes the 60S ribosomal protein L37a, which is one of the components of the large ribosomal subunit. The gene is expressed in various tissues, indicating the ubiquitous need for protein synthesis across different cell types.

Clinical Significance

Alterations in ribosomal proteins, including 60S ribosomal protein L37a, have been associated with various diseases, such as cancer and Diamond-Blackfan anemia. These conditions often arise from mutations that affect ribosome function or biogenesis, leading to impaired protein synthesis and cellular dysfunction.

Evolution

Ribosomal proteins, including 60S ribosomal protein L37a, are highly conserved across different species, reflecting their fundamental role in the ribosome's structure and function. This conservation across eukaryotes and even in some prokaryotes underscores the essential nature of protein synthesis in all forms of life.

See Also

• Ribosome
• Protein synthesis
• Ribosomal proteins

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