Pseudohypoxia

Pseudohypoxia refers to increased cytosolic ratio of free NAD to NADH in cells, caused by hyperglycemia.<ref name=a>[1] Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993</ref> Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process.<ref>[2] Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013</ref> It is expected that human NAD trials will begin in 2014.<ref>[3] Guardian Newspaper - Online, Dec 2013</ref>

Pseudohypoxia is a feature commonly noted in poorly-controlled diabetes.<ref name= a/>

See also

• Hypoxia (medical)
• Hypoxia (disambiguation) - list under Hypoxia (medical) e.g Intrauterine hypoxia

References

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