Transfersome

Transfersome is a type of drug delivery system that uses ultradeformable liposomes to deliver drugs across the skin. This technology was developed by IDEA AG, a German pharmaceutical company, and has been used in a number of products, including Tranfermal, a non-invasive pain relief patch.

History

The concept of transfersomes was first introduced in the early 1990s by Gregor Cevc and his colleagues at IDEA AG. The goal was to create a drug delivery system that could deliver drugs across the skin without the need for injections or other invasive procedures. The result was the development of ultradeformable liposomes, which are capable of penetrating the skin and delivering drugs to the desired location.

Mechanism of Action

Transfersomes work by taking advantage of the skin's natural ability to repair itself. When the skin is damaged, it releases certain chemicals that cause the skin cells to shrink and create gaps. These gaps allow the transfersomes to penetrate the skin and deliver the drug.

The transfersomes themselves are made up of phospholipids, which are the same type of molecules that make up the cell membranes in our bodies. This allows the transfersomes to merge with the skin cells and deliver the drug directly into the cell.

Applications

Transfersomes have been used in a number of different products, including Tranfermal, a non-invasive pain relief patch. This patch uses transfersomes to deliver the active ingredient, diclofenac, directly to the site of pain. This allows for faster and more effective pain relief compared to traditional oral medications.

Other potential applications for transfersomes include the delivery of insulin for diabetes patients, vaccines, and chemotherapy drugs for cancer patients.

Advantages and Disadvantages

One of the main advantages of transfersomes is that they allow for non-invasive drug delivery. This can be particularly beneficial for patients who have difficulty swallowing pills or who are afraid of injections.

However, there are also some disadvantages to this technology. For example, the effectiveness of transfersomes can be affected by the condition of the patient's skin. If the skin is too dry or damaged, the transfersomes may not be able to penetrate effectively.

See Also

• Drug delivery system
• Liposome
• Phospholipid
• IDEA AG

References

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