Interleukin 31

Interleukin 31 (IL-31) is a protein that in humans is encoded by the IL31 gene. It is a member of the gp130/IL-6 cytokine family. IL-31 is produced by a variety of cells, including T helper cells and mast cells. It is involved in several immune responses and has been implicated in a variety of diseases, including pruritus, atopic dermatitis, and allergic rhinitis.

Function

IL-31 interacts with a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and Oncostatin M receptor (OSMR). This interaction activates the JAK-STAT signaling pathway, leading to the expression of genes involved in inflammation and immune response. IL-31 has been shown to induce chemotaxis in monocytes and dendritic cells, suggesting a role in the recruitment of immune cells to sites of inflammation.

Clinical significance

Elevated levels of IL-31 have been observed in patients with a variety of inflammatory skin conditions, including atopic dermatitis and pruritus. In addition, IL-31 has been implicated in the pathogenesis of allergic rhinitis. Therapies targeting IL-31 or its receptor are currently being investigated for the treatment of these conditions.

See also

• Interleukin
• Cytokine
• Immune response
• Atopic dermatitis
• Pruritus
• Allergic rhinitis