Trevena, Inc.
American biopharmaceutical company
Trevena, Inc. is an American biopharmaceutical company focused on the development of novel therapeutics for the treatment of central nervous system (CNS) disorders. The company is headquartered in Chesterbrook, Pennsylvania.
History
Trevena, Inc. was founded in 2007 by a team of scientists from Duke University and other institutions. The company was established to leverage new insights into G protein-coupled receptors (GPCRs) to develop innovative therapies. Trevena went public in 2014, listing on the NASDAQ under the ticker symbol TRVN.
Research and Development
Trevena's research focuses on the development of biased ligands for GPCRs, which are designed to selectively activate specific signaling pathways. This approach aims to improve the therapeutic profile of drugs by enhancing efficacy and reducing side effects.
Oliceridine
One of Trevena's lead products is oliceridine, a novel opioid analgesic designed to provide pain relief with fewer side effects compared to traditional opioids. Oliceridine acts as a biased ligand at the mu-opioid receptor, preferentially activating the G protein pathway over the beta-arrestin pathway, which is associated with many of the adverse effects of opioids.
Other Pipeline Products
Trevena is also developing other CNS-targeted therapies, including TRV734, a follow-up to oliceridine, and TRV250, a treatment for migraine. These compounds are in various stages of clinical development.
Business Strategy
Trevena's business strategy involves advancing its pipeline through clinical trials and seeking strategic partnerships to support the commercialization of its products. The company aims to address unmet medical needs in pain management and other CNS disorders.
Corporate Governance
Trevena is governed by a board of directors with extensive experience in the pharmaceutical and biotechnology industries. The company's leadership team includes experts in drug development, regulatory affairs, and business operations.
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