Rottlerin
Rottlerin, also known as mallotoxin, is a natural polyphenolic compound that is extracted from the Kamala tree (Mallotus philippensis). It is a potent and selective inhibitor of protein kinase C delta type (PKCδ). Rottlerin has been used in laboratory research to understand the role of PKCδ in cell biology.
History[edit]
Rottlerin was first isolated from the Kamala tree in the 19th century. The compound was named after the German botanist Johann Friedrich Rottler, who made significant contributions to the study of Indian botany.
Structure and Properties[edit]
Rottlerin is a polyphenolic compound with a complex structure that includes a chromone moiety and two phenol groups. It has a molecular weight of 394.4 g/mol. The compound is yellow and has a melting point of 238-240 °C.
Biological Activity[edit]
Rottlerin is a potent and selective inhibitor of PKCδ, a member of the protein kinase C family. PKCδ is involved in a variety of cellular processes, including cell proliferation, apoptosis, and differentiation. Rottlerin inhibits PKCδ by binding to the regulatory domain of the enzyme, preventing its activation.
In addition to its activity against PKCδ, Rottlerin has been shown to have other biological effects. These include anti-inflammatory, anti-cancer, and anti-diabetic activities. However, the mechanisms of these effects are not fully understood.
Use in Research[edit]
Rottlerin has been widely used in laboratory research to study the role of PKCδ in cell biology. It has been used to investigate the role of PKCδ in diseases such as cancer, diabetes, and neurodegenerative disorders.
Safety and Toxicity[edit]
Rottlerin is considered to be a safe compound for laboratory use. However, it should be handled with care as it can cause skin and eye irritation. Ingestion or inhalation of Rottlerin can be harmful.
See Also[edit]
References[edit]
<references />
Ad. Transform your health with W8MD Weight Loss, Sleep & MedSpa
Tired of being overweight?
Special offer:
Budget GLP-1 weight loss medications
- Semaglutide starting from $29.99/week and up with insurance for visit of $59.99 and up per week self pay.
- Tirzepatide starting from $45.00/week and up (dose dependent) or $69.99/week and up self pay
✔ Same-week appointments, evenings & weekends
Learn more:
- GLP-1 weight loss clinic NYC
- W8MD's NYC medical weight loss
- W8MD Philadelphia GLP-1 shots
- Philadelphia GLP-1 injections
- Affordable GLP-1 shots NYC
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
