Mesterolone

Mesterolone is an androgen and anabolic steroid (AAS) medication which is used mainly in the treatment of low testosterone levels in men. It has also been used to treat male infertility, although this use is controversial. Mesterolone is taken by mouth.

Medical Uses

Mesterolone is used primarily in the treatment of low testosterone levels in men. Low testosterone can manifest in a variety of symptoms including decreased libido, fatigue, decreased muscle mass, and increased body fat. Mesterolone, by acting as a substitute for natural testosterone, can help alleviate these symptoms. Additionally, it has been used in the treatment of male infertility, particularly in cases where the infertility is due to low levels of testosterone.

Pharmacology

Mechanism of Action

Mesterolone is a synthetic derivative of dihydrotestosterone (DHT), which is a naturally occurring form of testosterone. It works by binding to androgen receptors in the body, which are found in various tissues including muscles, hair follicles, and the reproductive organs. This binding initiates a series of events that result in the expression of specific genes that are responsible for the development and maintenance of male characteristics and reproductive function.

Pharmacokinetics

The pharmacokinetics of mesterolone are characterized by its oral route of administration. It is well absorbed from the gastrointestinal tract, but it undergoes significant first-pass metabolism in the liver, which reduces its bioavailability. Mesterolone is highly bound to plasma proteins and is metabolized in the liver. Its metabolites are excreted in the urine and feces.

Adverse Effects

The use of mesterolone, like other androgenic steroids, can lead to adverse effects. These can include: - Acne - Hair loss - Voice changes - Growth of body hair - Increase in red blood cells, which can lead to complications such as blood clots - Liver damage, though this is less common with mesterolone compared to other oral steroids due to its chemical structure

It is important for individuals taking mesterolone to be monitored by a healthcare provider to manage and mitigate these potential side effects.

Contraindications

Mesterolone should not be used in individuals with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with prostate cancer, as androgens can accelerate the growth of prostate tumors. Additionally, it should not be used in pregnant or breastfeeding women due to the potential for virilization of the female fetus or infant.

Interactions

Mesterolone can interact with other medications, particularly those that are metabolized by the liver. It can affect the metabolism of other drugs, leading to altered levels of these medications in the body. Patients should inform their healthcare provider of all medications they are taking to avoid potential drug interactions.

See Also

• Testosterone
• Anabolic steroid
• Dihydrotestosterone
• Male infertility

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