Necrolytic migratory erythema
| Necrolytic migratory erythema | |
|---|---|
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Erythematous rash, blistering, crusting |
| Complications | Infection, scarring |
| Onset | |
| Duration | |
| Types | N/A |
| Causes | Glucagonoma |
| Risks | |
| Diagnosis | Clinical diagnosis, biopsy |
| Differential diagnosis | N/A |
| Prevention | N/A |
| Treatment | Surgical resection, octreotide, nutritional support |
| Medication | N/A |
| Prognosis | |
| Frequency | Rare |
| Deaths | N/A |
Necrolytic migratory erythema (NME) is a distinctive skin rash that is often associated with the glucagonoma syndrome, a rare pancreatic tumor that secretes excessive amounts of the hormone glucagon.
Presentation[edit]
NME is characterized by erythematous patches that evolve into blistering and crusting lesions. These lesions typically appear in areas subject to friction or pressure, such as the groin, buttocks, perineum, and lower abdomen. The rash is often pruritic and can be painful.
Pathophysiology[edit]
The exact mechanism of NME is not fully understood, but it is believed to be related to the metabolic effects of excess glucagon, including amino acid deficiency and zinc deficiency. These deficiencies may impair the skin's ability to repair itself, leading to the characteristic lesions.
Diagnosis[edit]
Diagnosis of NME is primarily clinical, supported by the presence of a glucagonoma. A biopsy of the skin lesions can help confirm the diagnosis by showing necrolysis of the upper layers of the epidermis.
Treatment[edit]
The primary treatment for NME is the surgical removal of the glucagonoma. Medical management may include the use of octreotide, a somatostatin analog that inhibits glucagon secretion. Nutritional support, including amino acid and zinc supplementation, may also be beneficial.
Prognosis[edit]
The prognosis of NME depends on the successful treatment of the underlying glucagonoma. Surgical resection of the tumor can lead to resolution of the skin lesions and improvement in symptoms.
See also[edit]
References[edit]
External links[edit]
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Necrolytic migratory erythema
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