Angiotensin (1-7)

Angiotensin (1-7) is a peptide hormone that plays a crucial role in the renin-angiotensin system (RAS). It is a seven-amino acid peptide that is a part of the angiotensin family, which includes other peptides such as angiotensin II and angiotensin III.

Function

Angiotensin (1-7) is known to have several physiological effects, most notably in the cardiovascular system. It acts as a vasodilator, helping to relax and widen blood vessels, which can lower blood pressure. It also has anti-inflammatory and anti-fibrotic effects, and can help to protect against heart and kidney disease.

The hormone is produced by the action of the enzyme angiotensin-converting enzyme 2 (ACE2) on angiotensin II. It acts primarily through the Mas receptor, a G protein-coupled receptor found in many tissues, including the heart, kidneys, and brain.

Clinical significance

Due to its beneficial effects on the cardiovascular system, angiotensin (1-7) has been investigated as a potential therapeutic agent for conditions such as hypertension, heart failure, and kidney disease. Studies have shown that it can help to reduce blood pressure, improve heart function, and protect against kidney damage in animal models of these diseases.

In addition, angiotensin (1-7) has been implicated in the pathophysiology of COVID-19. The virus that causes COVID-19, SARS-CoV-2, uses ACE2 to enter cells, which can lead to a decrease in the levels of angiotensin (1-7) and an increase in angiotensin II. This imbalance may contribute to the cardiovascular complications seen in some patients with COVID-19.

See also

• Angiotensin-converting enzyme 2
• Renin-angiotensin system
• Mas receptor

References

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  Angiotensin (1-7) structure
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  Angiotensin (1-7) synthesis pathway