ACPD

1-Amino-1,3-dicarboxycyclopentane

1-Amino-1,3-dicarboxycyclopentane (ACPD) is a chemical compound that acts as a selective agonist for metabotropic glutamate receptors. It is commonly used in neuroscience research to study the function of these receptors in the central nervous system.

Structure and Properties

1-Amino-1,3-dicarboxycyclopentane is a cyclopentane derivative with an amino group and two carboxylic acid groups. The presence of these functional groups allows it to interact with metabotropic glutamate receptors, which are a type of G protein-coupled receptor.

Mechanism of Action

ACPD acts as an agonist at metabotropic glutamate receptors, specifically targeting the mGluR1 and mGluR5 subtypes. These receptors are involved in modulating synaptic transmission and neuronal excitability. By activating these receptors, ACPD can influence various signaling pathways within the neuron.

Applications in Research

In neuroscience research, ACPD is used to:

• Investigate the role of metabotropic glutamate receptors in synaptic plasticity, such as long-term potentiation and long-term depression.
• Study the involvement of these receptors in neurodegenerative diseases and psychiatric disorders.
• Explore the potential therapeutic effects of modulating metabotropic glutamate receptor activity.

Safety and Handling

As with many research chemicals, proper safety protocols should be followed when handling ACPD. It should be used in a controlled laboratory environment, and appropriate personal protective equipment should be worn.

Related Pages

• Metabotropic glutamate receptor
• Neurotransmitter
• Synaptic plasticity
• G protein-coupled receptor

Gallery

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  Structure of 1-Amino-1,3-dicarboxycyclopentane