CCL18
CCL18 (Chemokine (C-C motif) ligand 18) is a protein that in humans is encoded by the CCL18 gene. This protein is a member of the chemokine family, which are small cytokines or signaling proteins secreted by cells. Chemokines are classified into four main subfamilies: CXC, CC, CX3C, and XC, based on the arrangement of the first two of the four conserved cysteine residues.
Function[edit]
CCL18 is primarily expressed in lung and lymph node tissues. It is produced by macrophages and dendritic cells in response to inflammatory stimuli. CCL18 plays a significant role in the immune system by attracting T cells, B cells, and natural killer cells to sites of inflammation. It is involved in various immune responses and has been implicated in the pathogenesis of several diseases, including asthma, pulmonary fibrosis, and certain cancers.
Clinical Significance[edit]
Elevated levels of CCL18 have been associated with idiopathic pulmonary fibrosis (IPF), a chronic and ultimately fatal disease characterized by a progressive decline in lung function. CCL18 is considered a potential biomarker for IPF and other fibrotic diseases. Additionally, high levels of CCL18 have been found in patients with breast cancer, where it may contribute to tumor progression and metastasis.
Gene Location[edit]
The CCL18 gene is located on chromosome 17 in humans. It is part of a cluster of chemokine genes in this region, which includes other members of the CC chemokine family.
Related Chemokines[edit]
CCL18 is closely related to other CC chemokines such as CCL3, CCL4, and CCL5. These chemokines share structural similarities and often have overlapping functions in the immune system.
Research and Therapeutic Potential[edit]
Research into CCL18 is ongoing, with studies focusing on its role in various diseases and its potential as a therapeutic target. Inhibiting CCL18 activity may offer new treatment strategies for conditions like IPF and certain cancers.
See Also[edit]
References[edit]
External Links[edit]
Ad. Transform your health with W8MD Weight Loss, Sleep & MedSpa
Tired of being overweight?
Special offer:
Budget GLP-1 weight loss medications
- Semaglutide starting from $29.99/week and up with insurance for visit of $59.99 and up per week self pay.
- Tirzepatide starting from $45.00/week and up (dose dependent) or $69.99/week and up self pay
✔ Same-week appointments, evenings & weekends
Learn more:
- GLP-1 weight loss clinic NYC
- W8MD's NYC medical weight loss
- W8MD Philadelphia GLP-1 shots
- Philadelphia GLP-1 injections
- Affordable GLP-1 shots NYC
|
WikiMD Medical Encyclopedia |
Medical Disclaimer: WikiMD is for informational purposes only and is not a substitute for professional medical advice. Content may be inaccurate or outdated and should not be used for diagnosis or treatment. Always consult your healthcare provider for medical decisions. Verify information with trusted sources such as CDC.gov and NIH.gov. By using this site, you agree that WikiMD is not liable for any outcomes related to its content. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
