Trimethoprim

Trimethoprim is an antibiotic used primarily in the treatment of bladder infections. Other uses include for middle ear infections, traveler's diarrhea, and respiratory tract infections. It can be taken by mouth either alone or in combination with sulfamethoxazole.

Medical uses

Trimethoprim is used to treat bladder infections, middle ear infections, traveler's diarrhea, and respiratory tract infections. It is often used in combination with sulfamethoxazole, a sulfonamide antibiotic. This combination is also used to prevent Pneumocystis pneumonia in people with HIV/AIDS.

Side effects

Common side effects of trimethoprim include nausea, changes in taste, and rash. Serious side effects may include high blood potassium, bone marrow suppression, and allergic reactions. It is not recommended in people with significant kidney problems, pregnant women, or people with G6PD deficiency.

Mechanism of action

Trimethoprim works by inhibiting the action of bacterial dihydrofolate reductase, thereby preventing the synthesis of bacterial DNA and inhibiting bacterial reproduction.

History

Trimethoprim was first used in 1962. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.

References

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External links

• Trimethoprim at Drugs.com

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