Tildipirosin

Tildipirosin is a macrolide antibiotic used in veterinary medicine to treat respiratory infections in cattle and swine. It is marketed under the trade name Zuprevo.

Chemistry

Tildipirosin is a semi-synthetic derivative of the naturally occurring compound tylosin. It is classified as a 16-membered macrolide. The chemical structure of tildipirosin is characterized by a large macrocyclic lactone ring, to which two sugars, mycinose and mycaminose, are attached. The molecule also contains a pyridine ring, which is believed to contribute to its antibacterial activity.

Mechanism of Action

Tildipirosin works by inhibiting protein synthesis in bacteria. It binds to the 50S subunit of the bacterial ribosome, preventing the addition of new amino acids to the growing peptide chain. This results in the premature termination of protein synthesis, leading to the death of the bacteria.

Uses

Tildipirosin is used to treat and prevent respiratory infections in cattle and swine caused by Mycoplasma and Pasteurella species. These infections can lead to conditions such as pneumonia, bronchitis, and pleurisy. Tildipirosin is administered by subcutaneous injection.

Side Effects

Possible side effects of tildipirosin include injection site reactions, decreased food consumption, and decreased weight gain. In rare cases, severe allergic reactions may occur.

Regulation

In the United States, tildipirosin is approved by the Food and Drug Administration (FDA) for use in cattle and swine. In the European Union, it is approved by the European Medicines Agency (EMA).

See Also

• Macrolide
• Veterinary Antibiotics
• Protein Synthesis Inhibitors

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