HDAC6

HDAC6 (Histone Deacetylase 6) is a enzyme that in humans is encoded by the HDAC6 gene. It is a member of the histone deacetylase family, which is involved in a multitude of cellular processes, such as cell cycle progression, gene expression, and protein folding.

Function

HDAC6 is unique among the class II HDAC enzymes in that it contains two complete, functional deacetylase domains. This enzyme has been shown to deacetylate tubulin, HSP90, and cortactin, proteins involved in cell motility and vesicle transport. It plays a central role in microtubule-dependent cell motility via the deacetylation of tubulin.

Clinical significance

HDAC6 has been implicated in a variety of human diseases, including cancer, neurodegenerative diseases, and inflammatory diseases. In cancer, HDAC6 is frequently overexpressed and has been associated with tumor progression and chemotherapy resistance. In neurodegenerative diseases, HDAC6 is thought to be involved in the formation of aggregated proteins and the induction of cell death.

Inhibitors

Several HDAC inhibitors have been developed to target HDAC6, including tubastatin A, ricolinostat, and ACY-1215. These inhibitors have shown promise in preclinical and clinical trials for the treatment of various diseases, particularly cancer.

See also

• Histone deacetylase
• HDAC inhibitors
• Tubulin

References

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