Parasubiculum
Parasubiculum
The Parasubiculum is a region of the brain that is part of the hippocampal formation. It is located in the medial temporal lobe, adjacent to the presubiculum and subiculum. The parasubiculum plays a crucial role in spatial navigation and memory.
Structure
The parasubiculum is a thin, elongated region that is located between the presubiculum and the entorhinal cortex. It is composed of three layers: the molecular layer, the pyramidal layer, and the multiform layer. The pyramidal layer contains densely packed pyramidal neurons, which are the primary excitatory neurons in the parasubiculum.
Function
The parasubiculum is involved in several cognitive functions, including spatial navigation and memory. It receives inputs from the entorhinal cortex, presubiculum, and subiculum, and sends outputs to the hippocampus and entorhinal cortex. The parasubiculum is thought to play a role in the transformation of spatial information from a egocentric to an allocentric frame of reference.
Clinical significance
Damage to the parasubiculum can result in spatial memory deficits and difficulties with navigation. It has been implicated in several neurological disorders, including Alzheimer's disease and temporal lobe epilepsy.
See also
References
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External links
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