LY-341495

LY-341495 is a pharmacological agent that is classified as a selective antagonist for the metabotropic glutamate receptors (mGluRs). It is primarily used in scientific research to understand the role and function of mGluRs in the central nervous system.

Chemistry

LY-341495 is a synthetic compound that belongs to the class of xanthine derivatives. It is a white crystalline solid that is soluble in water and organic solvents. The chemical formula of LY-341495 is C20H17NO6 and its molecular weight is 369.35 g/mol.

Pharmacology

LY-341495 acts as a potent and selective antagonist at the group II mGluRs, which includes mGluR2 and mGluR3. It has been shown to inhibit the activation of these receptors by their natural ligand, glutamate, thereby preventing the downstream effects of receptor activation.

Therapeutic Potential

Research has suggested that LY-341495 may have potential therapeutic applications in the treatment of various neurological disorders, including schizophrenia, anxiety disorders, and major depressive disorder. These potential applications are based on the role of mGluR2 and mGluR3 in modulating neuronal excitability and synaptic plasticity in the brain.

Side Effects

As with any pharmacological agent, LY-341495 may have potential side effects. However, as it is primarily used in research settings, the full extent of its side effect profile is not yet known.

See Also

• Metabotropic glutamate receptor
• Glutamate
• Neurological disorders
• Pharmacology

References

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