Α-Cyano-4-hydroxycinnamic acid

Α-Cyano-4-hydroxycinnamic acid (also known as CHCA and α-CHCA) is a chemical compound used in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry as a matrix. It is one of the most commonly used matrices in MALDI mass spectrometry due to its ability to absorb ultraviolet light and its suitability for ionizing a wide range of molecules.

Chemical Properties

Α-Cyano-4-hydroxycinnamic acid is a white crystalline solid at room temperature. It has a molecular weight of 189.18 g/mol and a chemical formula of C₁₀H₇NO₃. It is soluble in water, ethanol, and acetonitrile.

Applications

The primary use of α-cyano-4-hydroxycinnamic acid is as a matrix in MALDI mass spectrometry. In this application, the compound absorbs energy from the laser and helps to ionize the sample. This allows the mass spectrometer to detect and measure the mass of the molecules in the sample.

In addition to its use in mass spectrometry, α-cyano-4-hydroxycinnamic acid is also used in organic synthesis as a reagent.

Safety

Α-Cyano-4-hydroxycinnamic acid is not considered to be particularly hazardous, but it should be handled with care. It can cause irritation to the eyes, skin, and respiratory system. It should be used in a well-ventilated area and protective clothing, including gloves and eye protection, should be worn when handling the compound.

See Also

• Matrix-assisted laser desorption/ionization
• Mass spectrometry
• Organic synthesis

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