PHA-543,613
PHA-543,613 is a drug that acts as a potent and selective agonist for the alpha7 nicotinic acetylcholine receptor. It is used in scientific research and has no current medical or commercial uses.
Pharmacology
PHA-543,613 is a full agonist at the alpha7 nicotinic acetylcholine receptor, meaning it can fully activate the receptor while not being subject to regulation by the body's own neurotransmitters. This makes it useful in research into the function of these receptors, and potential future drug development.
Chemistry
PHA-543,613 is a quinuclidine derivative. Quinuclidine is a nitrogen-containing heterocyclic compound with the molecular formula C7H13N. The structure of PHA-543,613 includes a quinuclidine ring, which is believed to contribute to its activity at the alpha7 nicotinic acetylcholine receptor.
Research
Research into PHA-543,613 has focused on its potential use in the treatment of neurodegenerative diseases such as Alzheimer's disease and schizophrenia, where dysfunction of the alpha7 nicotinic acetylcholine receptor is believed to play a role. However, as of now, it is only used in preclinical research and has not been tested in humans.
See also
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