CM156

CM156‏‎ is a synthetic compound that acts as an antagonist for the neurotransmitter receptors sigma-1 and sigma-2. It was developed by researchers at the University of Southern California and has been studied for its potential applications in the treatment of neurodegenerative diseases, psychiatric disorders, and cancer.

History

CM156 was first synthesized in the early 2000s by a team of researchers at the University of Southern California. The compound was developed as part of a larger project to create new sigma receptor antagonists with potential therapeutic applications.

Structure and Mechanism of Action

CM156 is a small, synthetic molecule that binds to both sigma-1 and sigma-2 receptors in the brain. These receptors are involved in a variety of physiological processes, including the regulation of neurotransmission, cell proliferation, and apoptosis. By blocking these receptors, CM156 can potentially modulate these processes and exert therapeutic effects.

Potential Therapeutic Applications

Neurodegenerative Diseases

Research has suggested that sigma receptor antagonists like CM156 may have potential in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. These diseases are characterized by the progressive loss of neurons, and sigma receptor antagonists may help to protect these cells and slow the progression of the disease.

Psychiatric Disorders

Sigma receptor antagonists have also been studied for their potential in the treatment of psychiatric disorders such as schizophrenia and depression. These disorders are thought to involve dysregulation of neurotransmission, and sigma receptor antagonists may help to normalize these processes.

Cancer

In addition to its potential neurological and psychiatric applications, CM156 has also been studied for its potential anti-cancer effects. Sigma receptors are overexpressed in many types of cancer cells, and blocking these receptors may help to inhibit the growth of these cells.

See Also

• Sigma-1 receptor
• Sigma-2 receptor
• Neurotransmitter
• Neurodegenerative diseases
• Psychiatric disorders
• Cancer

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