Valorphin

Valorphin is a naturally occurring opioid peptide that is found in the brain of humans. It was first isolated from bovine brain by a team of scientists in 1982. Valorphin is derived from the protein hemoglobin and has been shown to have potent analgesic effects.

Structure and Function

Valorphin is a pentapeptide, meaning it is composed of five amino acids. The sequence of these amino acids is Val-Val-Tyr-Pro-Trp, hence the name "Valorphin". This peptide is derived from the beta chain of hemoglobin, specifically from positions 33-37.

The function of Valorphin is not fully understood, but it is known to have opioid-like effects. It has been shown to have potent analgesic effects, meaning it can relieve pain. This is thought to be due to its ability to bind to and activate opioid receptors in the brain.

Research and Clinical Significance

Research into Valorphin and its potential uses is ongoing. Due to its potent analgesic effects, it is being investigated for potential use in pain management. However, more research is needed to fully understand its mechanism of action and potential side effects.

Valorphin is also of interest in the study of opioid addiction. Understanding how naturally occurring opioids like Valorphin function could provide insights into the development of addiction and potential treatments.

See Also

• Opioid peptide
• Hemoglobin
• Analgesic

References

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