Parthenolide

Parthenolide is a sesquiterpene lactone which is the primary bioactive compound in the medicinal plant Feverfew (Tanacetum parthenium). It is known for its anti-inflammatory, anti-cancer, and anti-migraine effects.

Chemical Structure

Parthenolide has a complex chemical structure, which includes a seven-membered ring with an epoxide and a lactone group. Its molecular formula is C15H20O3.

Biological Activity

Parthenolide has been shown to have several biological activities. It is best known for its anti-inflammatory and anti-migraine effects, which are believed to be due to its ability to inhibit the release of inflammatory substances from white blood cells. It has also been shown to have anti-cancer effects, particularly against leukemia and breast cancer cells.

Medical Uses

Parthenolide is used in herbal medicine as a treatment for migraines and headaches, arthritis, fevers, muscle tension and pain, and to stimulate menstruation. It is also used in the treatment of cancer, particularly leukemia and breast cancer.

Safety and Side Effects

While parthenolide is generally considered safe, it can cause side effects such as mouth ulcers, digestive problems, and allergic reactions in some people. It should not be used by pregnant women, as it can stimulate uterine contractions.

Research

Research into the medicinal properties of parthenolide is ongoing. Recent studies have focused on its potential use in the treatment of cancer, particularly leukemia and breast cancer.

See Also

• Feverfew
• Sesquiterpene lactones
• Anti-inflammatory
• Anti-cancer

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