Oclacitinib

Oclacitinib (trade name Apoquel) is a medication used in the treatment of allergic dermatitis (including atopic dermatitis) and pruritus in dogs. It is a Janus kinase inhibitor, which means it interferes with the signaling pathway that leads to itching and inflammation.

Mechanism of action

Oclacitinib works by inhibiting the function of certain enzymes in the body known as Janus kinases. These enzymes play a key role in the process of inflammation and itching. By blocking their activity, oclacitinib can help to reduce these symptoms.

Uses

Oclacitinib is primarily used to treat allergic dermatitis and pruritus in dogs. It can be used both for short-term relief of acute symptoms and for long-term management of chronic conditions.

Side effects

The most common side effects of oclacitinib include vomiting, diarrhea, and anorexia. Less commonly, it can cause new cutaneous or subcutaneous lumps, and may increase susceptibility to infections and demodicosis. Rarely, it can cause severe adverse effects such as pneumonia, skin and ear infections, and aggression.

Veterinary use

In veterinary medicine, oclacitinib is used to manage pruritus associated with allergic dermatitis in dogs, including those with atopic dermatitis. It is also used to manage clinical manifestations of atopic dermatitis in dogs.

See also

• Janus kinase inhibitor
• Allergic dermatitis
• Pruritus
• Atopic dermatitis

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