JNJ-42165279

JNJ-42165279 is an experimental drug developed by Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson. It is a selective antagonist of the fatty acid amide hydrolase (FAAH) enzyme, which is involved in the breakdown of endocannabinoids in the body. By inhibiting FAAH, JNJ-42165279 increases the levels of endocannabinoids, which are involved in a variety of physiological processes including pain, mood, and inflammation.

Development and Clinical Trials

JNJ-42165279 has been investigated in several clinical trials for its potential therapeutic effects. In a Phase 2a study, the drug was found to be safe and well-tolerated in patients with social anxiety disorder and major depressive disorder. However, there were no significant differences in the primary efficacy endpoints between the JNJ-42165279 group and the placebo group.

In another Phase 2a study, JNJ-42165279 was evaluated in patients with neuropathic pain associated with small fiber neuropathy. The results of this study have not yet been published.

Mechanism of Action

JNJ-42165279 works by inhibiting the FAAH enzyme, which is responsible for breaking down endocannabinoids in the body. Endocannabinoids are naturally occurring compounds that bind to and activate cannabinoid receptors. These receptors are part of the endocannabinoid system, which plays a key role in regulating a variety of physiological processes, including pain, mood, and inflammation. By inhibiting FAAH, JNJ-42165279 increases the levels of endocannabinoids, potentially enhancing the activity of the endocannabinoid system.

Potential Therapeutic Applications

While the clinical trials conducted so far have not demonstrated significant efficacy of JNJ-42165279 in treating social anxiety disorder or major depressive disorder, the drug's mechanism of action suggests that it could potentially be useful in treating a variety of conditions associated with the endocannabinoid system. These could include chronic pain conditions, mood disorders, and inflammatory disorders. However, further research is needed to fully explore these potential applications.

See Also

• Fatty acid amide hydrolase
• Endocannabinoid system
• Janssen Pharmaceuticals
• Johnson & Johnson

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