Vernakalant

Vernakalant is a medication used to treat atrial fibrillation and atrial flutter, two common types of abnormal heart rhythm. It is an antiarrhythmic agent that works by blocking certain electrical signals in the heart to stabilize its rhythm.

Mechanism of Action

Vernakalant works by selectively blocking potassium channels in the heart that are active during repolarization, following an electrical impulse. This action prolongs the duration of the action potential, slowing the rate of electrical impulses and thus the heart rate.

Uses

Vernakalant is used to convert (change) recent-onset atrial fibrillation to normal sinus rhythm. It is used in adults who have had atrial fibrillation for 7 days or less. Vernakalant can also be used in people with atrial fibrillation following heart surgery.

Side Effects

Common side effects of vernakalant include dysgeusia (taste disturbances), sneezing, nausea, and paresthesia (tingling or numbness). Serious side effects can include arrhythmia (irregular heartbeat), hypotension (low blood pressure), and shock.

Contraindications

Vernakalant should not be used in people with severe heart failure, hypotension, or a history of Torsades de Pointes. It should also not be used in people who have taken certain other medications within the previous 48 hours.

See Also

• Antiarrhythmic agent
• Atrial fibrillation
• Atrial flutter
• Potassium channel

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