Interstitium

Interstitium is a fluid-filled space present between the structural barriers, such as cell walls, and the organs, including the skin and muscles, in the body. The interstitium is a part of the extracellular matrix (ECM), which is a network of non-living tissue that provides support to cells.

Structure

The interstitium is composed of a series of connected spaces, filled with fluid, that are lined by a layer of collagen and elastin fibers. These fibers are anchored to cells by fibronectin and integrin. The fluid in the interstitium, known as interstitial fluid, is derived from the blood and is rich in proteins and other molecules.

Function

The interstitium serves several important functions in the body. It provides a supportive framework for organs and tissues, and it also serves as a reservoir for water and electrolytes. The interstitium also plays a role in the immune response, as it contains lymphocytes and other immune cells. In addition, the interstitial fluid helps to transport nutrients and waste products between the blood and the cells.

Clinical significance

Changes in the interstitium can have significant clinical implications. For example, an increase in the amount of interstitial fluid can lead to edema, a condition characterized by swelling in the tissues. Conversely, a decrease in interstitial fluid can lead to dehydration. In addition, diseases such as pulmonary fibrosis and kidney disease can affect the structure and function of the interstitium.

Research

Recent research has suggested that the interstitium may be considered a new organ in the human body. This is due to its unique structure and function, as well as its potential role in the spread of diseases such as cancer. However, this idea is still a topic of ongoing debate among scientists.

See also

• Extracellular matrix
• Interstitial fluid
• Edema
• Pulmonary fibrosis
• Kidney disease

References

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