Trimegestone
Trimegestone is a progestin medication which is used in hormone therapy for women. It is a synthetic form of progesterone, a naturally occurring hormone in the female body. Trimegestone is used in combination with an estrogen in menopausal hormone therapy and for hormonal contraception.
Pharmacology
Trimegestone is a progestogen, specifically a 19-norprogesterone derivative. It has high affinity for the progesterone receptor and moderate affinity for the androgen receptor and glucocorticoid receptor. Trimegestone has no affinity for the estrogen receptor or mineralocorticoid receptor.
Medical uses
Trimegestone is used in combination with an estrogen in menopausal hormone therapy to prevent endometrial hyperplasia and uterine cancer in women with an intact uterus. It is also used in hormonal contraception in combination with an estrogen.
Side effects
The most common side effects of trimegestone include menstrual irregularities, breast tenderness, headache, and mood changes. Less common side effects include weight gain, acne, depression, and breast pain.
See also
References
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