Methylergometrine

Methylergometrine (also known as Methylergonovine) is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. It can be used either by mouth, by injection into a muscle, or injection into a vein.

Uses

Methylergometrine is commonly used to prevent or control excessive bleeding following childbirth and spontaneous or elective abortion, and also to aid in expulsion of retained products of conception after a missed abortion and to help deliver the placenta after childbirth.

Side Effects

Common side effects include high blood pressure, vomiting, seizures, headache and low blood pressure. Serious side effects may include water retention resulting in swelling, heart failure, and allergic reactions. It is not recommended in people with high blood pressure or kidney failure.

Mechanism of Action

Methylergometrine works by increasing the tone, rate, and amplitude of rhythmic contractions thus facilitating involution and reducing blood loss. The drug produces a firm titanic contraction, which slowly relaxes. This action is exerted on the smooth muscle of the uterus.

Pharmacokinetics

After oral administration, methylergometrine is rapidly absorbed from the gastrointestinal tract and widely distributed throughout the body. The drug is metabolized in the liver and excreted in the bile.

Contraindications

Methylergometrine is contraindicated in patients with hypersensitivity to ergot alkaloids, pregnancy, and hypertension.

Interactions

Methylergometrine may interact with grapefruit juice, ergotamine, and protease inhibitors.

See Also

• Ergot Alkaloids
• Postpartum Hemorrhage
• Abortion
• Childbirth

References

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