Rheumatoid neutrophilic dermatitis

Rheumatoid Neutrophilic Dermatitis

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Rheumatoid Arthritis, a common cause of Rheumatoid Neutrophilic Dermatitis

Rheumatoid Neutrophilic Dermatitis (RND) is a rare skin condition associated with Rheumatoid Arthritis. It is characterized by skin lesions that typically appear on the extremities. The condition is often misdiagnosed due to its rarity and the non-specific nature of the skin lesions.

Etiology

RND is most commonly associated with severe, active Rheumatoid Arthritis. However, it can also occur in patients with other systemic diseases such as Systemic Lupus Erythematosus and Sjögren's Syndrome. The exact cause of RND is unknown, but it is thought to be related to the immune response in these systemic diseases.

Clinical Presentation

Patients with RND typically present with skin lesions that are red, raised, and often painful. The lesions can appear anywhere on the body, but are most commonly found on the extremities. Other symptoms may include fever, joint pain, and fatigue.

Diagnosis

Diagnosis of RND is often challenging due to its rarity and the non-specific nature of the skin lesions. It is typically diagnosed through a combination of clinical presentation, patient history, and skin biopsy. The biopsy will show a dense infiltrate of neutrophils in the dermis, which is characteristic of RND.

Treatment

Treatment of RND is primarily focused on managing the underlying systemic disease. This may include medications to reduce inflammation and suppress the immune system. Topical or systemic corticosteroids may also be used to manage the skin lesions.

Prognosis

The prognosis for RND is generally good, with most patients experiencing a resolution of skin lesions with appropriate treatment. However, the underlying systemic disease may continue to cause symptoms and require ongoing management.