Signs and symptoms of HIV/AIDS
The signs and symptoms of Acquired immunodeficiency syndrome



[[File:PCPxray.jpg|thumb|X-ray of pneumocystis pneumonia (PCP).

Human Immunodeficiency Virus (HIV) infection evolves through several stages: acute infection, latency, and Acquired Immunodeficiency Syndrome (AIDS). These stages are characterized by varying symptoms and markers, reflecting the progression and severity of the disease.
Acute Infection Stage[edit]
Acute HIV infection, also known as primary infection, is the initial stage following exposure to the virus. It typically lasts several weeks and is often accompanied by flu-like symptoms such as fever, swollen lymph nodes, inflammation of the throat, rash, muscle pain (myalgia), general discomfort (malaise), and sores in the mouth and esophagus.<ref>,
Virological Blips and Predictors of Post Treatment Viral Control After Stopping ART Started in Primary HIV Infection, Journal of Acquired Immune Deficiency Syndromes, 2016, Vol. 71(Issue: 2), pp. 130–137, DOI: 10.1097/QAI.0000000000000835, PMID: 26334738, PMC: PMC4761502,</ref>
Latency Stage[edit]
Following the acute infection stage, HIV enters a phase of latency. This stage, often symptom-free, can last from a few weeks to several decades, depending largely on the individual and the level of treatment. During latency, the virus continues to replicate at low levels and the immune system remains engaged in a constant battle to control viral replication.<ref>,
HIV reservoirs: what, where and how to target them, Nature Reviews Microbiology, 2016, Vol. 14(Issue: 1), pp. 55–60, DOI: 10.1038/nrmicro.2015.5, PMID: 26525230, PMC: PMC4837377,</ref>
AIDS Stage[edit]
AIDS represents the final stage of HIV infection and is marked by a significantly weakened immune system. It is defined by a CD4+ T cell count of fewer than 200 per µL, along with the presence of various opportunistic infections, cancers, and other health complications. Opportunistic infections are illnesses that occur more frequently and are more severe in individuals with weakened immune systems, including those affected by HIV.<ref>,
Guidelines for the prevention and treatment of opportunistic infections in HIV-infected adults and adolescents, Morbidity and Mortality Weekly Report, 2009, Vol. 58(Issue: RR-4), pp. 1–198, PMID: 19357635, PMC: PMC3106261,</ref>
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