DIRAS3 (gene)

DIRAS3 (also known as ARHI or NOEY2) is a gene that encodes a member of the small GTPase protein family. This gene is located on chromosome 1 at position 1p31.3. The protein encoded by this gene is a GTPase that acts as a tumor suppressor and is involved in cellular processes such as cell cycle regulation, apoptosis, and autophagy.

Function

The DIRAS3 gene encodes a protein that belongs to the DIRAS family. This protein is a small GTPase that functions as a tumor suppressor. It is involved in the regulation of several cellular processes, including the cell cycle, apoptosis, and autophagy. The protein is known to inhibit cell growth and to promote apoptosis and autophagy, processes that are often dysregulated in cancer.

Clinical significance

Mutations in the DIRAS3 gene have been associated with several types of cancer, including ovarian cancer, breast cancer, and lung cancer. Reduced expression of this gene has been observed in a variety of human cancers, suggesting that it may play a role in tumor suppression.

Research

Research into the DIRAS3 gene and its encoded protein is ongoing, with studies focusing on its role in cancer development and progression, as well as its potential as a therapeutic target.

See also

• GTPase
• Tumor suppressor
• Cell cycle
• Apoptosis
• Autophagy

References

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