Pancreatic polypeptide cells

Pancreatic polypeptide cells (also known as PP cells or F cells) are a type of endocrine cell found in the pancreas. They are responsible for the production and secretion of pancreatic polypeptide (PP), a hormone that plays a role in the regulation of pancreatic secretion and gastrointestinal motility.

Structure

PP cells are located predominantly in the Islets of Langerhans, the endocrine part of the pancreas. They make up approximately 20-30% of the islet cells. These cells are more abundant in the head of the pancreas than in the tail.

Function

The primary function of PP cells is to produce and secrete pancreatic polypeptide. This hormone is released in response to protein ingestion and fasting. It acts to regulate the secretion of other pancreatic hormones, inhibit gallbladder contraction, and slow down the rate of gastric emptying and intestinal motility.

Clinical significance

Abnormalities in PP cells can lead to a variety of medical conditions. For example, an excess of PP cells can result in pancreatic polypeptide hypersecretion, which can cause diarrhea and malabsorption. Conversely, a deficiency in PP cells can lead to diabetes mellitus, as the lack of pancreatic polypeptide can disrupt the regulation of insulin and glucagon.

See also

• Pancreas
• Islets of Langerhans
• Endocrine system
• Pancreatic hormones

References

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